The hypoglycemic activity of substances is to regulate and reduce the blood sugar level in the blood. diabetes patients cannot secrete enough insulin or insulin resistance causes abnormal blood sugar levels. At the same time, the development of diseases is often accompanied by various complications, including heart disease, stroke, diabetes nephropathy, and diabetes peripheral neuropathy. Now, various treatment methods can achieve the control of blood sugar balance according to different mechanisms, but with some side effects observed in diabetes patients. Therefore, there is an urgent need for a natural food that can regulate blood sugar levels with minimal side effects. Ethanol extracts from Agaricus bisporus, Agaricus bisporus, and Hericium erinaceus have been reported to have a hypoglycemic effect. Integrating genetic and transcriptional data, it was found that the expression of IGF2BP2 mRNA is related to blood glucose and insulin homeostasis. The liver is an important organ for glycogen metabolism, responsible for glycogen synthesis and glycogen decomposition. Studies have reported that most patients with diabetes have liver metabolic disorder, so it is very important to study the transcriptional control of glucose after food intervention.
A large number of reports indicate that many metabolic diseases are related to disturbances in the gut microbiota. The metabolic products of microorganisms, butyric acid and propionic acid, are associated with reducing blood sugar and liver weight. At the same time, microorganisms produce different molecules that affect the host's absorption and digestion of food. Intestinal microbes significantly affect the glucose metabolism of the host, and its imbalance is related to obesity and diabetes. It is reported that polysaccharide and resistant starch in mushrooms can regulate the imbalance of intestinal microorganisms, increase the content of intestinal SCFA, and increase insulin sensitivity in diabetes mouse models.
Grey tree flowers (GF) are rich in nutrients, have immune regulation, and exhibit anti-tumor, antiviral, antioxidant, and lipid-lowering activities. It can also be used to regulate glucose levels. Observations have been made from G The ethanol extract obtained from Frundosa (labeled GF) contains various bioactive substances such as flavonoids, alkaloids, fatty acids, and terpenes, which exhibit hypoglycemic, antioxidant, antibacterial, and anti-inflammatory activities. The extract can also be used to scavenge oxygen free radicals. There are different components in alcohol extracts obtained from different concentrations of ethanol. Therefore, it is important to explore the impact of these components on the degree of sugar metabolism regulation.
Studied G. treated with 55% and 95% ethanol Frundosa's effect on blood sugar. Compare the components present in two extracts to understand which component significantly contributes to glucose regulation. Further exploration of G. was conducted through biochemical and transcriptional analysis Frundosa has a hypoglycemic effect of 55% and 95%, respectively. We also analyzed the gut microbiota to obtain results. The results presented in this article can serve as a basis for understanding the hypoglycemic activity of edible mushrooms using bioinformatics tools.